Epistemology

Chemistry

Philosophy

Biochemistry

Bone resorption

Receptor

Energy metabolism

Biology

Endocrinology

Bone remodeling

Adenosine triphosphate

Metabolism

Cell biology

Oxidative phosphorylation

Mechanism (biology)

Internal medicine

Glycolysis

Osteoclast

Osteoporosis

Medicine

Frontiers in Endocrinology

In recent decades, the mechanism underlying bone metabolic disorders based on energy metabolism has been heavily researched. Bone resorption by osteoclasts plays an important role in the occurrence and development of osteoporosis. However, the mechanism underlying the osteoclast energy metabolism disorder that interferes with bone homeostasis has not been determined. Bone resorption by osteoclasts is a process that consumes large amounts of adenosine triphosphate (ATP) produced by glycolysis and oxidative phosphorylation. In addition to glucose, fatty acids and amino acids can also be used as substrates to produce energy through oxidative phosphorylation. In this review, we summarize and analyze the energy-based phenotypic changes, epigenetic regulation, and coupling with systemic energy metabolism of osteoclasts during the development and progression of osteoporosis. At the same time, we propose a hypothesis, the compensatory recovery mechanism (involving the balance between osteoclast survival and functional activation), which may provide a new approach for the treatment of osteoporosis.

The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis