Development of an LC‐MS/MS method for simultaneous quantitative analysis of macromolecular pharmaceutical adjuvant 2‐hydroxypropyl‐β‐cyclodextrin and active pharmaceutical ingredients butylphthalide in rat plasma

Hydroxypropyl-β-cyclodextrin, which possesses a high water solubility and low hemolycity, is widely used as a solubilizer and an excipient. It had also been reported that hydroxypropyl-β-cyclodextrin has the activity of regulating lipid homeostasis. In order to further understand the metabolism, the primary focus was to establish a quantitative method for hydroxypropyl-β-cyclodextrin. The analytes were extracted from plasma by protein...