Gene-experience correlation during cognitive development: Evidence from the Adolescent Brain Cognitive Development (ABCD) StudySM

Published on Mar 25, 2021in bioRxiv
· DOI :10.1101/637512
R. J. Loughnan4
Estimated H-index: 4
(University of California, Berkeley),
Robert J. Loughnan1
Estimated H-index: 1
(University of California, Berkeley)
+ 4 AuthorsChun Chieh Fan26
Estimated H-index: 26
(UCSD: University of California, San Diego)
Sources
Abstract
Background: Findings in adults have shown more culturally sensitive 9crystallized9 measures of intelligence have greater heritability, these results were not able to be shown in children. Methods: With data from 8,518 participants, aged 9 to 11, from the Adolescent Brain Cognitive Development (ABCD) Study®, we used polygenic predictors of intelligence test performance (based on genome-wide association meta-analyses of data from 269,867 individuals) and of educational attainment (based on data from 1.1 million individuals), associating these predictors with neurocognitive performance. We then assessed the extent of mediation of these associations by a measure of recreational reading. Results: more culturally sensitive 9crystallized9 measures were more strongly associated with the polygenic predictors than were less culturally sensitive 9fluid9 measures. This mirrored heritability differences reported previously in adults and suggests similar associations in children. Recreational reading more strongly statistically mediated the genetic associations with crystallized than those with fluid measures of cognition. Conclusion: This is consistent with a prominent role of gene-environment correlation in cognitive development measured by "crystallized" intelligence tests. Such experiential mediators may represent malleable targets for improving cognitive outcomes.
📖 Papers frequently viewed together
8 Citations
19 Citations
1 Author (Reut Avinun)
2 Citations
References30
Newest
#1Laramie E. Duncan (Stanford University)H-Index: 29
#2Hanyang Shen (Stanford University)H-Index: 11
Last. Benjamin W. Domingue (Stanford University)H-Index: 24
view all 8 authors...
A historical tendency to use European ancestry samples hinders medical genetics research, including the use of polygenic scores, which are individual-level metrics of genetic risk. We analyze the first decade of polygenic scoring studies (2008–2017, inclusive), and find that 67% of studies included exclusively European ancestry participants and another 19% included only East Asian ancestry participants. Only 3.8% of studies were among cohorts of African, Hispanic, or Indigenous peoples. We find ...
186 CitationsSource
#1Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 68
#2M Deanna (WashU: Washington University in St. Louis)H-Index: 106
Last. Monica M Luciana (UMN: University of Minnesota)H-Index: 47
view all 7 authors...
Abstract The Adolescent Brain Cognitive Development (ABCD) study is poised to be the largest single-cohort long-term longitudinal study of neurodevelopment and child health in the United States. Baseline data on N = 4521 children aged 9–10 were released for public access on November 2, 2018. In this paper we performed principal component analyses of the neurocognitive assessments administered to the baseline sample. The neurocognitive battery included seven measures from the NIH Toolbox as well ...
31 CitationsSource
#1Alicia R. Martin (Harvard University)H-Index: 29
#2Masahiro KanaiH-Index: 25
Last. Mark J. DalyH-Index: 213
view all 6 authors...
Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medicine. However, the major ethical and scientific challenge surrounding clinical implementation of PRS is that those available today are several times more accurate in individuals of European ancestry than other ancestries. This disparity is an inescapable consequence of Eurocentric biases in genome-wide association studies, thus highlighting that—unlike clinical biomarkers and prescription drugs, which may ind...
450 CitationsSource
#1Allison M. Auchter (UCSD: University of California, San Diego)H-Index: 1
#2Margie Hernandez Mejia (UCSD: University of California, San Diego)H-Index: 4
Last. Gayathri J. Dowling (NIDA: National Institute on Drug Abuse)H-Index: 10
view all 8 authors...
Author(s): Auchter, AM; Mejia, MH; Heyser, CJ; Shilling, PD; Jernigan, TL; Brown, SA; Tapert, SF; Dowling, GJ | Abstract: The Adolescent Brain Cognitive Development (ABCD) study is designed to be the largest study of brain development and child health in the United States, performing comprehensive assessments of 11,500 children repeatedly for 10 years. An endeavor of this magnitude requires an organized framework of governance and communication that promotes collaborative decision-making and dis...
59 CitationsSource
#1James J. Lee (UMN: University of Minnesota)H-Index: 32
#2Robbee Wedow (CU: University of Colorado Boulder)H-Index: 13
Last. David Cesarini (NYU: New York University)H-Index: 45
view all 78 authors...
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and e...
740 CitationsSource
#1Jeanne E. Savage (VU: VU University Amsterdam)H-Index: 19
#2Philip R. Jansen (VU: VU University Amsterdam)H-Index: 18
Last. Danielle Posthuma (VU: VU University Amsterdam)H-Index: 101
view all 117 authors...
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3–7, but much about its genetic underpinnings remains to be discovered. Here, we present a large-scale genetic association study of intelligence (n = 269,867), identifying 205 associated genomic loci (190 new) and 1,016 genes (939 new) via positional mapping, expression quantitative trait locus (eQTL) map...
379 CitationsSource
#1Nora D. Volkow (NIDA: National Institute on Drug Abuse)H-Index: 183
#2George F. Koob (NIH: National Institutes of Health)H-Index: 196
Last. Susan R. B. Weiss (NIDA: National Institute on Drug Abuse)H-Index: 13
view all 22 authors...
Abstract Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use. However, there is much we have yet to learn about how these experiences influence brain development, how they promote or interfere with later health outcomes, or even what healthy brain development looks like. A large longitudinal study beginning in early adolescence could help us understand the normal variability i...
173 CitationsSource
#1Alicia R. MartinH-Index: 29
#2Christopher R. Gignoux (Stanford University)H-Index: 42
Last. Eimear E. KennyH-Index: 37
view all 9 authors...
The vast majority of genome-wide association studies (GWASs) are performed in Europeans, and their transferability to other populations is dependent on many factors (e.g., linkage disequilibrium, allele frequencies, genetic architecture). As medical genomics studies become increasingly large and diverse, gaining insights into population history and consequently the transferability of disease risk measurement is critical. Here, we disentangle recent population history in the widely used 1000 Geno...
571 CitationsSource
#1Sayantan Das (UM: University of Michigan)H-Index: 17
#2Lukas Forer (Innsbruck Medical University)H-Index: 19
Last. Christian Fuchsberger (UM: University of Michigan)H-Index: 53
view all 21 authors...
Christian Fuchsberger, Goncalo Abecasis and colleagues describe a new web-based imputation service that enables rapid imputation of large numbers of samples and allows convenient access to large reference panels of sequenced individuals. Their state space reduction provides a computationally efficient solution for genotype imputation with no loss in imputation accuracy.
1,129 CitationsSource
#1Slavé Petrovski (Columbia University)H-Index: 39
#2David Goldstein (Columbia University)H-Index: 157
An important application of modern genomics is diagnosing genetic disorders. We use the largest publicly available exome sequence database to show that this key clinical service can currently be performed much more effectively in individuals of European genetic ancestry.
133 CitationsSource
Cited By6
Newest
#1Anthony Steven Dick (FIU: Florida International University)H-Index: 21
#2Daniel A Lopez (URMC: University of Rochester Medical Center)H-Index: 2
Last. Andrew T. Marshall (SC: University of Southern California)H-Index: 14
view all 0 authors...
Abstract null null The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, e...
3 CitationsSource
#1Erhan GençH-Index: 16
#2Caroline Schlüter (RUB: Ruhr University Bochum)H-Index: 8
Last. Sebastian Ocklenburg (RUB: Ruhr University Bochum)H-Index: 31
view all 11 authors...
Intelligence is a highly polygenic trait and genome-wide association studies (GWAS) have identified thousands of DNA variants contributing with small effects. Polygenic scores (PGS) can aggregate those effects for trait prediction in independent samples. As large-scale light-phenotyping GWAS operationalized intelligence as performance in rather superficial tests, the question arises which intelligence facets are actually captured. We used deep-phenotyping to investigate the molecular determinant...
Source
#1R. J. LoughnanH-Index: 4
#2Alexey A. ShadrinH-Index: 12
Last. Anders M. DaleH-Index: 2
view all 12 authors...
Genome-Wide Association studies have typically been limited to single phenotypes, given that high dimensional phenotypes incur a large multiple comparisons burden: ~1 million tests across the genome times the number of phenotypes. Recent work demonstrates that a Multivariate Omnibus Statistic Test (MOSTest) is well powered to discover genomic effects distributed across multiple phenotypes. Applied to cortical brain MRI morphology measures, MOSTest has resulted in a drastic improvement in power t...
Source
#1Anthony Steven Dick (FIU: Florida International University)H-Index: 21
#2Daniel A Lopez (URMC: University of Rochester Medical Center)H-Index: 2
Last. Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 68
view all 24 authors...
The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children9s health in the United States. A cohort of n=11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household ...
6 CitationsSource
#1Erhan Genç (RUB: Ruhr University Bochum)H-Index: 16
#2Caroline Schlüter (RUB: Ruhr University Bochum)H-Index: 8
Last. Sebastian Ocklenburg (RUB: Ruhr University Bochum)H-Index: 31
view all 10 authors...
Intelligence is a highly polygenic trait and GWAS have identified thousands of DNA variants contributing with small effects. Polygenic scores (PGS) can aggregate those effects for trait prediction in independent samples. As large-scale light-phenotyping GWAS operationalized intelligence as performance in rather superficial tests, the question arises which intelligence facets are actually captured. We used deep-phenotyping to investigate the association between PGS of educational attainment (EA-P...
3 CitationsSource