Targeting STING attenuates ROS induced intervertebral disc degeneration
Abstract
DNA damage induced by ROS is considered one of the main causes of nucleus pulposus (NP) cells degeneration during the progression of intervertebral disc degeneration (IVDD). cGAS-STING pathway acts as DNA-sensing mechanism for monitoring DNA damage. Recent studies have proved that cGAS-STING contributes to the development of various diseases by inducing inflammation, senescence, and apoptosis. This work explored the role of STING, the main...
Paper Details
Title
Targeting STING attenuates ROS induced intervertebral disc degeneration
Published Date
Aug 1, 2021
Journal
Volume
29
Issue
8
Pages
1213 - 1224
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