Hydrogel matrix presence and composition influence drug responses of encapsulated glioblastoma spheroids

Glioblastoma multiforme (GBM) is the most aggressive brain tumor with median patient survival of 12–15 months. To facilitate treatment development, bioengineered GBM models that adequately recapitulate the in vivo tumor microenvironment are needed. Matrix-encapsulated multicellular spheroids represent such model because they recapitulate solid tumor characteristics, such as dimensionality, cell-cell, and cell-matrix interactions. Yet, there is...