Der Zusammenhang zwischen COVID-19 und Schlaganfall: Pathophysiologie und klinische Bedeutung

Published on May 21, 2021in Fortschritte Der Neurologie Psychiatrie0.642
· DOI :10.1055/A-1484-0224
Timo Siepmann17
Estimated H-index: 17
(TUD: Dresden University of Technology),
Kristian Barlinn21
Estimated H-index: 21
(TUD: Dresden University of Technology)
#1Isabel Siow (NUS: National University of Singapore)H-Index: 1
#2Keng Siang Lee (UoB: University of Bristol)H-Index: 3
Last. Barnaby E Young (NTU: Nanyang Technological University)H-Index: 31
view all 6 authors...
Abstract Introduction COVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19. Methods We conducted a systematic review of all studies published between November...
19 CitationsSource
#1Claudio Baracchini (UNIPD: University of Padua)H-Index: 23
#2Alessio PieroniH-Index: 11
PURPOSE OF REVIEW: The coronavirus disease 2019 (COVID-19) pandemic has caused a major impact on stroke care. This review synthesizes the available data and provides a framework for optimal management of stroke patients with confirmed or suspected COVID-19 infection and eligible to reperfusion treatments. RECENT FINDINGS: Reorganization of health services has led to the conversion of stroke units and relocation of stroke staff to COVID units. During the pandemic surge, there has been a general d...
4 CitationsSource
ABSTRACT Introduction : To examine the impact of the COVID-19 pandemic on stroke, the number of stroke patients, time since last known well (LKW), morbidity, and mortality of stroke patients in Southwest Healthcare System (SHS), California (CA) and the United States (US) were analyzed during 2019 and compared to 2020. Our hypothesis is that there are regional differences in stroke outcome depending on location during the COVID-19 study period which influences stroke epidemiology and clinical str...
2 CitationsSource
#1Wenjing Chen (WMU: Wenzhou Medical College)H-Index: 1
#2Jing Ye Pan (WMU: Wenzhou Medical College)H-Index: 1
The spread of the coronavirus (SARS-CoV-2, COVID-19 for short) has caused a large number of deaths around the world. We summarized the data reported in the past few months and emphasized that the main causes of death of COVID-19 patients are DAD (Diffuse Alveolar Damage) and DIC (Disseminated intravascular coagulation). Microthrombosis is a prominent clinical feature of COVID-19, and 91.3% of dead patients had microthrombosis.Endothelial damage caused by SARS-CoV-2 cell invasion and subsequent h...
15 CitationsSource
#1Timo Siepmann (TUD: Dresden University of Technology)H-Index: 7
#2Annahita Sedghi (TUD: Dresden University of Technology)H-Index: 5
Last. Kristian Barlinn (TUD: Dresden University of Technology)H-Index: 21
view all 21 authors...
BACKGROUND AND PURPOSE: Recent observations linked coronavirus disease 2019 (COVID-19) to thromboembolic complications possibly mediated by increased blood coagulability and inflammatory endothelial impairment. We aimed to define the risk of acute stroke in patients with severe and non-severe COVID-19. METHODS: We performed an observational, multicenter cohort study in four participating hospitals in Saxony, Germany to characterize consecutive patients with laboratory-confirmed COVID-19 who expe...
19 CitationsSource
#1Jan van der Linden (KI: Karolinska Institutet)H-Index: 22
#2Lou M. Almskog (KI: Karolinska Institutet)H-Index: 3
Last. Marcus Ståhlberg (KI: Karolinska Institutet)H-Index: 15
view all 9 authors...
To determine the prevalence of thrombotic events, functional coagulation tests, inflammatory biomarkers, and antiphospholipid antibodies before and after enhanced anticoagulation in critically ill coronavirus disease 2019 patients Design: Retrospective Setting: Tertiary intensive care unit Patients: Two cross-sectional cohorts of ICU-treated coronavirus disease 2019 patients were included before (cohort 1, n = 12) and after (cohort 2, n = 14) enhanced prophylactic anticoagulation strategy Interv...
9 CitationsSource
#1Peter BerlitH-Index: 28
#2Julian BöselH-Index: 1
Last. Götz ThomallaH-Index: 52
view all 11 authors...
Infection with the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to a previously unknown clinical picture, which is known as COVID-19 (COrona VIrus Disease-2019) and was first described in the Hubei region of China. The SARS-CoV-2 pandemic has implications for all areas of medicine. It directly and indirectly affects the care of neurological diseases. SARS-CoV-2 infection may be associated with an increased incidence of neurological manifestations such as encephalopathy ...
24 CitationsSource
#1Steffen Tiedt (LMU: Ludwig Maximilian University of Munich)H-Index: 14
#2Felix J. Bode (University Hospital Bonn)H-Index: 9
Last. Gabor C. Petzold (University Hospital Bonn)H-Index: 25
view all 6 authors...
The Coronavirus Disease 2019 (COVID-19) pandemic may have altered emergency workflows established to optimize the outcome of patients with large-vessel occlusion (LVO) stroke. We here analyzed workflow time intervals and functional outcomes of LVO patients treated with endovascular thrombectomy (ET) during the COVID-19 pandemic in Germany. We compared the frequency, pre- and intrahospital workflow time intervals, rates of reperfusion, and functional outcome of patients admitted from March 1st to...
8 CitationsSource
#1Nishant R Tiwari (Government Medical College, Thiruvananthapuram)H-Index: 2
#2Khalid I KhatibH-Index: 4
Last. Ujwala MhatreH-Index: 4
view all 8 authors...
The novel coronavirus disease, 2019 (COVID - 19) evolved as an unprecedented pandemic. The severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) infection has been associated with significantly deranged coagulation parameters and increased incidence of thrombotic events. Deranged coagulation parameters, such as D-dimers and fibrin degradation products, can indicate a poor prognosis, and their measurement will help stratify the patients according to the disease severity, need of intensive...
6 CitationsSource
#1Kimon BekelisH-Index: 12
#2Symeon Missios (Population Health Research Institute)H-Index: 23
Last. Todd A. MacKenzie (The Dartmouth Institute for Health Policy and Clinical Practice)H-Index: 66
view all 8 authors...
Background and Purpose: The impact of coronavirus disease 2019 (COVID-19) on the occurrence of ischemic stroke has been the subject of increased speculation but has not been confirmed in large obse...
14 CitationsSource
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