Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine‐modifying inhibitors

Monocarboxylate transporter isoforms 1–4, MCT, of the solute carrier SLC16A family facilitate proton‐coupled transport of l ‐lactate. Growth of tumors that exhibit the Warburg effect, that is, high rates of anaerobic glycolysis despite availability of oxygen, relies on swift l ‐lactate export, whereas oxygenic cancer cells import circulating l ‐lactate as a fuel. Currently, MCTs are viewed as promising anticancer targets. Small‐molecule...