Lappaol F, an anticancer agent, inhibits YAP via transcriptional and post-translational regulation
Abstract
Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumour cell growth by inducing cell cycle arrest. However, its underlying anticancer mechanism remains unclear.The effects of LAF on the Hippo-Yes-associated protein (YAP) signalling pathway, which plays an important role in cancer progression, were explored in this study.Cervical (HeLa), colorectal (SW480), breast (MDA-MB-231) and prostate (PC3) cancer cell lines...
Paper Details
Title
Lappaol F, an anticancer agent, inhibits YAP via transcriptional and post-translational regulation
Published Date
Jan 1, 2021
Journal
Volume
59
Issue
1
Pages
617 - 626
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