Sulfated modification enhances the modulatory effect of yam polysaccharide on gut microbiota in cyclophosphamide-treated mice

Published on Jul 1, 2021in Food Research International4.972
· DOI :10.1016/J.FOODRES.2021.110393
Rong Huang2
Estimated H-index: 2
(NCU: Nanchang University),
Jianhua Xie35
Estimated H-index: 35
(NCU: Nanchang University)
+ 1 AuthorsMingyue Shen29
Estimated H-index: 29
(NCU: Nanchang University)
Abstract Our previous study has demonstrated that sulfated yam polysaccharide (SCYP) had a stronger immunomodulatory activity than yam polysaccharide (CYP). In order to investigate how the sulfated modification influence the immunological activity of CYP, this research was mainly focused on the study of gut microbiotal. The results showed that SCYP treatment could increase the digestive enzyme activities of colon contents and restore the production of short-chain fatty acids (SCFAs) in mice that were decreased by cyclophosphamide (Cy) treatment. Furthermore, SCYP treatment could modulate the structure of the gut microbiota, which was mainly manifest in the result of an increased abundances of Lactobacillus, Bacteroidetes and Akkermansia, and the decrease of the proportion of Proteobacteria and Verrucomicrobia in the microbial community. Diversity and overall structure of microbial community were also improved by SCYP treatment based on alpha-diversity and beta-diversity analysis results. The biomarkers of the gut microbial that were regulated by SCYP have been identified by linear discriminant analysis (LDA) effect size (LEfSe). These findings further indicate that there is great potential for SCYP to be developed into prebiotics or functional foods.
#1Yiqing Zhu (NU: Nanjing University)H-Index: 3
#2Jian Ding (NU: Nanjing University)H-Index: 2
Last. Qiuhui Hu (Nanjing University of Finance and Economics)H-Index: 44
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#1Rong Huang (NCU: Nanchang University)H-Index: 2
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
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Abstract A sulfated Chinese yam polysaccharide (S-CYP) was obtained from non-starch Chinese yam polysaccharide (CYP) by chlorosulfonic acid-pyridine (CSA-Pyr) method. The physicochemical characteristics and immunological activity of S-CYP were evaluated in this study. Results showed that sulfated modification changed the physicochemical properties of Chinese yam polysaccharide. Body weights and thymus index of the mice in polysaccharides group were increased compared with the cyclophosphamide (C...
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#2Xiaojun Huang (NCU: Nanchang University)H-Index: 9
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#1Ya Zhao (NAU: Nanjing Agricultural University)H-Index: 2
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Abstract In this study, Chinese yam polysaccharides (CYP) were extracted from the tuber of Dioscorea opposita Thunb. by hot-water extraction and ethanol precipitation. After deproteinized by the Sevag method, the content of CYP was determined to be 91.77%. The anti-aging activities of the CYP were evaluated in aging mice induced by d -galactose in vitro and in vivo. The results indicated that the CYP not only could enhance the learning ability of mice, but alleviate the spatial memory impairment...
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#1Fu Zhifei (Tianjin University of Traditional Chinese Medicine)H-Index: 2
#2Lifeng Han (Tianjin University of Traditional Chinese Medicine)H-Index: 17
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