Incidental Prostate Cancer: A Real Need for Expansion in Guidelines?

Published on May 18, 2021in European Urology Oncology
· DOI :10.1016/J.EUO.2021.04.006
Nicolas Mottet40
Estimated H-index: 40
Olivier Rouvière56
Estimated H-index: 56
Theodorus H. van der Kwast41
Estimated H-index: 41
(EUR: Erasmus University Rotterdam)
#1Umberto Capitanio (UniSR: Vita-Salute San Raffaele University)H-Index: 62
#2Riccardo AutorinoH-Index: 68
Last. Francesco Montorsi (UniSR: Vita-Salute San Raffaele University)H-Index: 138
view all 15 authors...
1 CitationsSource
#1Jan Herden (University of Cologne)H-Index: 7
#2Andreas Schwarte (St. Agnes Hospital)H-Index: 1
Last. Lothar WeissbachH-Index: 11
view all 4 authors...
INTRODUCTION Optimal treatment for incidental prostate cancer (IPC) after surgical treatment for benign prostate obstruction is still debatable. We report on long-term outcomes of IPC patients managed with active surveillance (AS) in a German multicenter study. METHODS HAROW (2008-2013) was designed as a noninterventional, prospective, health-service research study for patients with localized prostate cancer (≤cT2), including patients with IPC (cT1a/b). A follow-up examination of all patients tr...
#1Stephanie M. Walker (NIH: National Institutes of Health)H-Index: 3
#2Baris Turkbey (NIH: National Institutes of Health)H-Index: 76
To summarize the role of prostate MRI in the assessment and treatment of benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS). BPH/LUTS is a very common source of morbidity in aging men. mpMRI has become an increasingly popular modality for prostate imaging due to its ability to provide exceptional anatomic detail. This has allowed for MRI classification of BPH and detailed assessment of response to various BPH treatment modalities, including simple prostatectomy...
1 CitationsSource
#1David E. Neal (University of Oxford)H-Index: 111
#2Chris Metcalfe (UoB: University of Bristol)H-Index: 61
Last. Tracy E RobertsH-Index: 40
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Abstract Background The ProtecT trial reported intention-to-treat analysis of men with localised prostate cancer randomly allocated to active monitoring (AM), radical prostatectomy, and external beam radiotherapy. Objective To report outcomes according to treatment received in men in randomised and treatment choice cohorts. Design, setting, and participants This study focuses on secondary care. Men with clinically localised prostate cancer at one of nine UK centres were invited to participate in...
36 CitationsSource
#1Doo Yong Chung (Yonsei University)H-Index: 9
#2Hyeok Jun Goh (Yonsei University)H-Index: 3
Last. Young Deuk Choi (Yonsei University)H-Index: 35
view all 7 authors...
Purpose The aim of this study was to evaluate predictors of residual tumor and clinical prognosis in T1a-T1b (incidental) prostate cancer by analysis of specimens from men undergoing surgery for benign prostatic hyperplasia. Materials and methods We retrospectively reviewed medical records of incidental prostate cancer patients who had undergone radical prostatectomy. Patients whose tumor statuses were further confirmed by prostate biopsy, or who had used androgen deprivation therapy before radi...
2 CitationsSource
#1Lars Egevad (KI: Karolinska Institutet)H-Index: 79
#2Brett Delahunt (University of Otago)H-Index: 68
Last. Mark Clements (KI: Karolinska Institutet)H-Index: 23
view all 28 authors...
Aims: Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. Methods and results: The International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pat...
18 CitationsSource
#1J. Joy Lee (Stanford University)H-Index: 3
#2I-Chun Thomas (Stanford University)H-Index: 8
Last. John T. Leppert (Stanford University)H-Index: 29
view all 6 authors...
BACKGROUND Prostate cancer arises in the transition zone (TZ) in approximately 20–25% of cases. Modern biopsy and surveillance protocols, and advances in prostate cancer imaging, have renewed interest in TZ prostate cancers. We compared TZ and PZ prostate cancer to determine if cancer location is independently associated with better outcomes. METHODS We evaluated an expanded cohort of 1354 men who underwent radical prostatectomy between 1983 and 2003 with updated long-term clinical follow-up. Re...
29 CitationsSource
#1Umberto CapitanioH-Index: 62
#2Vincenzo ScattoniH-Index: 51
Last. Francesco MontorsiH-Index: 138
view all 10 authors...
Abstract Background Controversies exist about the most appropriate management for patients with incidental prostate cancer after surgery for benign prostatic hyperplasia (BPH). Objectives To test the accuracy of preoperative clinical variables in predicting the presence of residual disease and biochemical recurrence in patients with incidental prostate cancer treated with radical retropubic prostatectomy. Design, Setting, and Participants We analyzed 126 T1a–T1b prostate cancers diagnosed at sur...
76 CitationsSource
Cited By1
#1Umberto Capitanio (UniSR: Vita-Salute San Raffaele University)H-Index: 62
#2Riccardo AutorinoH-Index: 68
Last. Francesco Montorsi (UniSR: Vita-Salute San Raffaele University)H-Index: 138
view all 15 authors...