MiR-221/222 Ameliorates Deoxynivalenol-Induced Apoptosis and Proliferation Inhibition in Intestinal Epithelial Cells by Targeting PTEN

Published on May 19, 2021in Frontiers in Cell and Developmental Biology5.201
· DOI :10.3389/FCELL.2021.652939
Lianjie Hou , Xiong Tong + 3 AuthorsMei-Ying Xie2
Estimated H-index: 2
#1Alix Garcia (University of Geneva)H-Index: 3
#2Sylvie Dunoyer-Geindre (University of Geneva)H-Index: 16
Last. Pierre Fontana (Geneva College)H-Index: 31
view all 6 authors...
MicroRNAs (miRNAs) are small noncoding RNAs modulating protein production. They are key players in regulation of cell function and are considered as biomarkers in several diseases. The identification of the proteins they regulate, and their impact on cell physiology, may delineate their role as diagnostic or prognostic markers and identify new therapeutic strategies. During the last 3 decades, development of a large panel of techniques has given rise to multiple models dedicated to the study of ...
2 CitationsSource
#1Wei Cheng (Nanjing University of Chinese Medicine)H-Index: 28
#2Kai Wang (Xuzhou Medical College)H-Index: 4
Last. Jieshou Li (NU: Nanjing University)H-Index: 59
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Glucagon-like peptide-2 (GLP-2), a key factor in intestinal rehabilitation therapy of short bowel syndrome (SBS), may require cell-to-cell communication to exert its biological functions. However, understanding of the mechanism remains elusive. Here, we report participation of exosomal miR-125a/b in GLP-2 mediated intestinal epithelial cells-myofibroblasts cross-talk in intestinal microenvironment. Methods: The effects of GLP-2 on the proliferation and apoptosis of intestinal epithelial cells in...
1 CitationsSource
#1Mei-Ying Xie (SCAU: South China Agricultural University)H-Index: 6
#2Ting Chen (SCAU: South China Agricultural University)H-Index: 12
Last. Zhang YongliangH-Index: 1
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Abstract Porcine milk exosomes play an important role in mother-infant communication. Deoxynivalenol (DON) is a toxin which causes serious damage to the animal intestinal mucosa. Our previous study showed porcine milk exosomes facilitate mice intestine development, but the effects of these exosomes to antagonize DON toxicity is unclear. Our in vivo results showed that milk exosomes attenuated DON-induced damage on the mouse body weight and intestinal epithelium growth. In addition, these exosome...
7 CitationsSource
#1Libin Ma (ZJU: Zhejiang University)H-Index: 3
#2Huadong He (ZJU: Zhejiang University)H-Index: 1
Last. Gang Deng (ZJU: Zhejiang University)H-Index: 1
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Family with sequence similarity 46 member C (FAM46C) is a non-canonical poly(A) polymerase that is associated with tumorigenesis. However, its role in prostate cancer development is not fully understood. Herein, we determined expression pattern of FAM46C in prostate cancer and further identified its effect on the tumorigenesis and chemosensitivity. FAM46C expression was decreased in prostate cancer tissues and cell lines compared with corresponding controls. FAM46C expression was significantly a...
2 CitationsSource
#1Katriona Lyons (Teagasc)H-Index: 2
#2C. Anthony Ryan (UCC: University College Cork)H-Index: 30
Last. Catherine Stanton (Teagasc)H-Index: 108
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Human breast milk is considered the optimum feeding regime for newborn infants due to its ability to provide complete nutrition and many bioactive health factors. Breast feeding is associated with improved infant health and immune development, less incidences of gastrointestinal disease and lower mortality rates than formula fed infants. As well as providing fundamental nutrients to the growing infant, breast milk is a source of commensal bacteria which further enhance infant health by preventin...
32 CitationsSource
#1Glenn R. Masson (LMB: Laboratory of Molecular Biology)H-Index: 16
#2Roger Williams (LMB: Laboratory of Molecular Biology)H-Index: 2
Last. Roger L. Williams (LMB: Laboratory of Molecular Biology)H-Index: 83
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The tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN) is a tightly regulated enzyme responsible for dephosphorylating the progrowth lipid messenger molecule phosphatidylinositol 3,4,5-trisphosphate (PIP3) on the plasma membrane. The carboxy-terminal tail (CTT) of PTEN is key for regulation of the enzyme. When phosphorylated, the unstructured CTT interacts with the phosphatase-C2 superdomain to inactivate the enzyme by preventing membrane association. PTEN mutations associat...
9 CitationsSource
#1Hongyan Guo (Jiangnan University)H-Index: 3
#2Jian Ji (Jiangnan University)H-Index: 25
Last. Xiulan Sun (Jiangnan University)H-Index: 27
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Deoxynivalenol (DON) has drawn global attention because of its prevalence and significant effects on human or animal health. Biological remedies for DON have been developed from preharvest to postharvest. Applying microbes, including bacteria, fungi (yeast and molds), and enzymes, results in inhibited synthesis, structural destruction, or adsorption of DON. DON can be degraded into masked forms by phase I metabolism or phase II metabolism. During food processing, DON content changes dynamically ...
14 CitationsSource
#1Yinming WangH-Index: 1
#2Junquan GuH-Index: 1
Last. Shuhua GuiH-Index: 1
view all 8 authors...
Effect of micro ribonucleic acid (miR)-130a on neuronal apoptosis in rats with cerebral infarction (CI) was studied to explore whether phosphatase and tensin homolog deleted on chromosome ten (PTEN)/phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (Akt) is involved in the regulation of neuronal apoptosis. Thirty-six Sprague-Dawley (SD) rats were randomly divided into blank control group, model group and miR-130a low-expression group. miR-130a was determined by quantitative polymeras...
5 CitationsSource
#1Sakshi Mishra (Central Drug Research Institute)H-Index: 11
#2Sonal Srivastava (Central Drug Research Institute)H-Index: 7
Last. Srikanta Kumar Rath (Central Drug Research Institute)H-Index: 13
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AbstractPreventing food from fungal infestation has become a cause of great concern as food safety is of particular importance to public health globally. Recently International Agency for Research ...
30 CitationsSource
#1Philip P. Ahern (Cleveland Clinic Lerner Research Institute)H-Index: 20
#2Kevin J. Maloy (Glas.: University of Glasgow)H-Index: 45
The past two decades have seen an explosion in research that aims to understand how the dynamic interplay with the gut microbiota impacts host health and disease, establishing a role for the gut microbiota in a plethora of pathologies. Understanding how health‐promoting microbiota are established and how beneficial host–microbiota interactions are maintained is of immense biomedical importance. Despite the enormous progress that has been made, our knowledge of the specific microbiota members tha...
27 CitationsSource
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