Cholangiocyte organoids as a cell source for biliary repair

Preoccupied with the astounding regenerative capabilities and metabolic importance of hepatocytes in the liver, the role of the resident plumbers of the liver, the cholangiocytes, can be overlooked in comparison. Cholangiocytes form the ductal network which makes up the biliary tree and transports bile from the liver to the gallbladder for secretion into the intestine during digestion. Chronic accumulation of bile in the liver is cytotoxic,...