Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition
Abstract
The microtubule-associated protein tau promotes the stabilization of the axonal cytoskeleton in neurons. In several neurodegenerative diseases, such as Alzheimer's disease, tau has been found to dissociate from microtubules, leading to the formation of pathological aggregates that display an amyloid fibril-like structure. Recent structural studies have shown that the tau filaments isolated from different neurodegenerative disorders have...
Paper Details
Title
Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition
Published Date
May 19, 2021
Journal
Volume
60
Issue
21
Pages
1658 - 1669
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Notes
History