Metabolic activation of deferiprone mediated by CYP2A6.

Volume: 51, Issue: 11, Pages: 1282 - 1291
Published: May 18, 2021
Abstract
Deferiprone (DFP) is a metal chelating agent generally used to treat patients with thalassaemia, due to iron overload in clinical settings.Studies have revealed that long-term use of DFP can induce hepatotoxicity, however, mechanisms of its toxic action remain unclear. The present studies are aimed to characterize the reactive metabolite of DFP, to define the metabolic pathway, and to determine the P450 enzymes participating in the...
Paper Details
Title
Metabolic activation of deferiprone mediated by CYP2A6.
Published Date
May 18, 2021
Volume
51
Issue
11
Pages
1282 - 1291
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