Clinically used JAK inhibitor blunts dsRNA‐induced inflammation and calcification in aortic valve interstitial cells

Calcific aortic valve disease (CAVD) is the most prevalent valvulopathy worldwide. Growing evidence supports a role for viral and cell‐derived double‐stranded (ds)‐RNA in cardiovascular pathophysiology. Poly(I:C), a dsRNA surrogate, has been shown to induce inflammation, type I interferon (IFN) responses, and osteogenesis through Toll‐like receptor 3 in aortic valve interstitial cells (VIC). Here, we aimed to determine whether IFN signaling via...