Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma
Abstract
Hepatocellular carcinoma (HCC) is related to increasing incidence rates and poor clinical outcomes due to lack of efficient treatment options and emerging resistance mechanisms. The aim of the present study is to exploit a non-viral gene therapy enabling the expression of the parvovirus-derived oncotoxic protein NS1 in HCC. This anticancer protein interacts with different cellular kinases mediating a multimodal host-cell death. Lipoplexes (LPX)...
Paper Details
Title
Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma
Published Date
Jun 1, 2021
Volume
334
Pages
138 - 152
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