Surgically induced ischemia has no impact on protein expression levels of HIF‐1α and related biomarkers in renal cell carcinoma

The increasing demands for personalized targeted therapy directed against renal cell carcinoma have driven a search for predictive markers. Novel therapies targeting HIF‐1α in renal cell carcinoma have been developed, and HIF‐1α has been suggested as a novel predictive marker of response to therapy. The surgical resection of a kidney tumor induces tissue ischemia, and HIF‐1α is an oxygen‐sensitive transcription factor, which is known to be...