The Association between QuantiFERON-TB Gold Test and Clinical Manifestations of Uveitis in the United States

Published on Oct 1, 2021in American Journal of Ophthalmology4.013
· DOI :10.1016/J.AJO.2021.04.024
Mehmet Yakin7
Estimated H-index: 7
(NIH: National Institutes of Health),
Natasha Kesav1
Estimated H-index: 1
(NIH: National Institutes of Health)
+ 3 AuthorsH. Nida Sen36
Estimated H-index: 36
(NIH: National Institutes of Health)
Sources
Abstract
Abstract Purpose To report the prevalence of QuantiFERON-TB Gold (QFT-G) positivity among uveitis patients compared to general population and to evaluate the differences in clinical features of uveitis. Design Retrospective cohort study. Methods:Setting Institutional. Patient Population 418 consecutive new uveitis patients, regardless of clinical suspicion, were tested for QFT-G. Observation Procedures Demographics, TB risk factors, clinical characteristics of uveitis were collected. Main Outcome Measures The frequency of QFT-G positivity among uveitis patients and characteristic clinical features among QFT-G positive patients. Results QFT-G positivity was found in 60/418 patients with uveitis (14.4%, 95% CI: 11.18 – 18.14) higher than the general US population (5%, 95% CI: 4.2 – 5.8, p .05 for each). Prevalence of TB-uveitis based on treatment response was 1.19%. Conclusions Our study demonstrates significantly higher prevalence of QFT-G positivity among uveitis patients compared to average US population. Characteristic signs of TB uveitis reported in endemic countries were not seen in this cohort. Implications of higher prevalence of QFT-G positivity among uveitis patients require further investigation.
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