Single-Nucleus Transcriptomic Dissection of PTSD and MDD in Human Post-Mortem DLPFC Reveals Genetic and Environmental Regulation

Many advances have been made towards understanding the genetic and pathophysiological architecture of stress-related psychiatric disorders such as post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Perturbations in dorsolateral prefrontal cortex (dlPFC) function have been implicated in the development of both MDD and PTSD. However, less work has focused on identifying how dlPFC with its cell types contributes to observed...