AgRP signalling negatively regulates bone mass

The central nervous system is an active and major regulator of bone structure and remodelling. Specifically, signalling within the hypothalamus has been shown to be critical to ensuring that skeletal functions align with whole body metabolic supply and demand. Here, we identify agouti‐related peptide (AgRP), an orexigenic peptide exclusively co‐expressed with neuropeptide Y (NPY) in the arcuate nucleus (ARC) of the hypothalamus, as another...