Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma
Abstract
Aberrant activation of the Hedgehog (Hh) pathway is implicated in the pathogenesis and development of multiple cancers, especially Hh-driven medulloblastoma (MB). Smoothened (SMO) is a promising therapeutic target of the Hh pathway in clinical cancer treatment. However, SMO mutations frequently occur, which leads to drug resistance and tumor relapse. Novel inhibitors that target both the wild-type and mutant SMO are in high demand. In this...
Paper Details
Title
Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma
Published Date
Aug 1, 2021
Journal
Volume
190
Pages
114593 - 114593
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