Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer

Therapeutic resistance is the main cause of death in metastatic colorectal cancer. To investigate genomic plasticity, most specifically of metastatic lesions, associated with response to first-line systemic therapy, we collected longitudinal liver metastatic samples and characterized the copy number aberration (CNA) landscape and its effect on the transcriptome.Liver metastatic biopsies were collected prior to treatment (pre, n = 97) and when...