MITOCHONDRIA ISOLATED FROM MESENCHYMAL STROMAL CELLS REDUCE LUNGAND DISTAL ORGAN INJURY IN EXPERIMENTAL SEPSIS

Background Although mesenchymal stromal cells (MSC) administration has demonstrated beneficial effects in experimental sepsis, cell-free therapeutics based on biologically active products from MSCs have been proposed to circumvent inherent risks related to whole-cell transplantation. As mitochondria transfer has emerged as one of the key mechanisms by which MSCs induce therapeutic actions, we asked whether MSC-isolated mitochondria could reduce...