Refining Imputation Models of Molecular Phenotypes in the Dorsolateral Prefrontal Cortex to Improve Understanding of Risk Across Neuropsychiatric Disorders

Transcriptome imputation leverages tissue-specific genotype-expression reference panels to build databases of genetically regulated gene expression. These models can be applied to GWAS to prioritize gene-trait associations (GTAs) with functional importance. Expression predictions in the dorsolateral prefrontal cortex (dlPFC) are relevant in neuropsychiatric disorders, yet, available models exhibit both technical and methodological...