Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment
Abstract
Two decades of research have proven the relevance of ion channel expression for tumor progression in virtually every indication, and it has become clear that inhibition of specific ion channels will eventually become part of the oncology therapeutic arsenal. However, ion channels play relevant roles in all aspects of physiology, and specificity for the tumor tissue remains a challenge to avoid undesired effects. Eag1 (K V 10.1) is a...
Paper Details
Title
Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment
Published Date
May 4, 2021
Journal
Volume
42
Issue
1
Pages
183 - 226
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History