The impact of chitooligosaccharides and their derivatives on the in vitro and in vivo antitumor activity: A comprehensive review

Published on Aug 15, 2021in Carbohydrate Polymers7.182
· DOI :10.1016/J.CARBPOL.2021.118132
Xingchen Zhai (BFU: Beijing Forestry University), Chaonan Li (BFU: Beijing Forestry University)+ 3 AuthorsA. M. Abd El-Aty31
Estimated H-index: 31
(Atatürk University)
Source
Abstract
Abstract Chitooligosaccharides (COS) are the degraded products of chitin or chitosan. COS is water-soluble, non-cytotoxic to organisms, readily absorbed through the intestine, and eliminated primarily through the kidneys. COS possess a wide range of biological activities, including immunomodulation, cholesterol-lowering, and antitumor activity. Although work on COS goes back at least forty years, several aspects remain unclear. This review narrates the recent developments in COS antitumor activities, while paying considerable attention to the impacts of physicochemical properties (such as molecular weight and degrees of deacetylation) and chemical modifications both in vitro and in vivo. COS derivatives not only improve some physicochemical properties, but also expand the range of applications in drug and gene delivery. COS (itself or as a drug carrier) can inhibit tumor cell proliferation and metastasis, which might be attributed to its ability to stimulate the immune response along with its anti-angiogenic activity. Further, an attempt has been made to report limitations and future research. The potential health benefits of COS and its derivatives against cancer may offer a new insight on their applications in food and medical fields.
References113
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#1Xiuhong Huang (JNU: Jinan University)H-Index: 3
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Abstract It has been proved that chitosan oligosaccharide (COS) has a more favorable therapeutic applications such as wound healing and anti-tumor treatment, and can affect angiogenesis. For better understanding the effect of COS on angiogenic activities at cellular level, COS with different concentration and degree of polymerization (DP) were used to culture human umbilical vein endothelial cells (HUVECs) in this work. Cell proliferation activity, cell morphology, cell migration and angiogenesi...
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#1Gunsriwiang Benchamas (CNU: Chongqing Normal University)H-Index: 3
#2Gangliang Huang (CNU: Chongqing Normal University)H-Index: 11
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Last. Zhongxi Zhao (SDU: Shandong University)H-Index: 17
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Abstract A novel folic acid mediated chitosan oligosaccharide-grafted disulfide-containing polyethylenimine copolymer-based silica nanohybrids were fabricated for co-delivering paclitaxel and P-shRNA. These nanoparticles could efficiently protect P-shRNA against degradation, and exhibited well redox-responsive P-shRNA release and pH-responsive drug release behaviors. Folic acid as the targeting head, could improve cellular uptake of nanoparticles by multidrug-resistant breast cancer cells. Moreo...
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Abstract Herein, the effects of carboxymethyl chitosan oligosaccharide (CM-COS) on regulating immunologic function and inhibiting hepatocellular tumor growth were evaluated. Results showed that CM-COS caused dramatic viability loss of hepatocellular carcinoma BEL-7402 with non-toxicity towards normal liver L-02 cells. CM-COS repressed tumor growth of hepatoma-22, and elevated the spleen index and thymus index of tumor-bearing mice. Contents of VEGF and MMP-9 were significantly down-regulated by ...
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#1Xubing Yuan (CAS: Chinese Academy of Sciences)H-Index: 5
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#1Pan ZouH-Index: 8
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Abstract Increasing studies have reported the antitumor effects of chitosan oligosaccharides (COS) against multiple cancer, including S180, colon tumor, etc. Here, the structural characters of COS were identified and its inhibitory effects against orthotopic liver tumor and immunoregulation effects were also studied. Degree of polymerization (DP) of COS is 2–6, degree of deacetylation (DD) is 98.38 ± 1.34%. COS is positive charged with zeta potential at 11.27 ± 1.56 mV, with diameter at about 10...
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The aminoethyl–chitooligosaccharide (AE-COS) was reported to inhibit human gastric cancer cell proliferation and human fibrosarcoma cell invasion. In this study, the role of AE-COS in down-regulation of proliferation of human lung A549 cancer cells was evaluated. It was found that AE-COS was able to reduce A549 cell proliferation to (32 ± 1.3)% at a concentration of 500 µg/mL. Moreover, AE-COS treatment caused suppression on COX-2 expression in a dose-dependent manner. Notably, the role of AE-CO...
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