Recent developments in predicting CYP-independent metabolism
Abstract
As lead optimization efforts have successfully reduced metabolic liabilities due to cytochrome P450 (CYP)-mediated metabolism, there has been an increase in the frequency of involvement of non-CYP enzymes in the metabolism of investigational compounds. Although there have been numerous notable advancements in the characterization of non-CYP enzymes with respect to their localization, reaction mechanisms, species differences and identification of...
Paper Details
Title
Recent developments in predicting CYP-independent metabolism
Published Date
Apr 3, 2021
Journal
Volume
53
Issue
2
Pages
188 - 206
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