CXCL13 promotes intestinal tumorigenesis through the activation of epithelial AKT signaling
Abstract
The excessive release of proinflammatory chemokines promotes cell proliferation and tumor growth in colorectal cancer. However, their regulatory functions and molecular pathogenesis have not been well elucidated. Here, we observed the upregulation of chemokine (C-X-C motif) ligand 13 (CXCL13) in human colorectal cancers and mouse intestinal tumors. Both CXCL13 deficiency and blockade of CXCL13 signaling ameliorated disease progression. CXCL13...
Paper Details
Title
CXCL13 promotes intestinal tumorigenesis through the activation of epithelial AKT signaling
Published Date
Jul 1, 2021
Journal
Volume
511
Pages
1 - 14
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