Identifying protein complexes from protein–protein interaction networks based on the gene expression profile and core-attachment approach

Defining protein complexes in the cell is important for learning about cellular processes mechanisms as they perform many of the molecular functions in these processes. Most of the proposed algorithms predict a complex as a dense area in a Protein-Protein Interaction (PPI) network. Others, on the other hand, weight the network using gene expression or geneontology (GO). These approaches, however, eliminate the proteins and their edges that offer...