Deep-tissue localization of magnetic field hyperthermia using pulse sequencing

Objective Deep-tissue localization of thermal doses is a long-standing challenge in magnetic field hyperthermia (MFH), and remains a limitation of the clinical application of MFH to date. Here, we show that pulse sequencing of MFH leads to a more persistent inhibition of tumor growth and less systemic impact than continuous MFH, even when delivering the same thermal dose.Methods We used an in vivo orthotopic murine model of pancreatic PANC-1...