3D Printed Perfusable Renal Proximal Tubule Model With Different Extracellular Matrix Compositions

This paper describes the design of a chip modeling the proximal renal tubule, namely the nephron segment that is most targeted by drug toxicants. The tubule model is based on a 3D convoluted geometry whose printing parameters and Pluronic concentration were optimized to achieve a diameter of 320 μm without discontinuities. A perfusion system guaranteeing a 1 μL/min flow was also integrated. Moreover, the tubule model was integrated into a gel...