Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review
Abstract
Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and development of endometriotic cells in ectopic sites can be promoted via multiple pathways, including MAPK/MEK/ERK, PI3K/Akt/mTOR, NF-κB, Rho/ROCK, reactive oxidative stress, tumor necrosis factor, transforming growth factor-β, Wnt/β-catenin, vascular endothelial growth factor, estrogen, and cytokines. The underlying pathophysiological mechanisms include...
Paper Details
Title
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review
Published Date
May 5, 2021
Journal
Volume
41
Issue
4
Pages
2489 - 2564
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