Validation of a Targeted Next-Generation Sequencing Panel for Tumor Mutation Burden Analysis
Abstract
Tumor mutation burden (TMB) is evaluated as a biomarker of response to immunotherapy. We present the efforts of the Onconetwork Immuno-Oncology Consortium to validate a commercial targeted sequencing test for TMB calculation. A three-phase study was designed to validate the Oncomine Tumor Mutational Load (OTML) assay at nine European laboratories. Phase 1 evaluated reproducibility and accuracy on seven control samples. In phase 2, six...
Paper Details
Title
Validation of a Targeted Next-Generation Sequencing Panel for Tumor Mutation Burden Analysis
Published Date
Jul 1, 2021
Volume
23
Issue
7
Pages
882 - 893
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