Rapid Buprenorphine Microdosing for Opioid use Disorder in a Hospitalized Patient Receiving Very High Doses of Full Agonist Opioids for Acute Pain Management: Titration, Implementation Barriers, and Strategies to Overcomes

Background: Conventional buprenorphine inductions for OUD are clinically useful but require patients to experience mild to moderate opioid withdrawal symptoms to avoid precipitated withdrawal. This may be intolerable/unreasonable for some, which may have precluded successful buprenorphine treatment in the past. Microdosing buprenorphine, allowing for full agonist opioid overlap, has emerged as a clinically useful strategy for those unable to...