PTSD-Associated Variants and Cross-Tissue Examination of DNA Methylation

PTSD GWAS studies have implicated genes including MAD1L1. Single nucleotide polymorphism (SNP) associations can be mediated by DNA methylation (DNAm), which can regulate gene expression in response to environmental conditions. SNP-DNAm effects, when observed across tissues such as in the periphery and the brain, can inform how environmental factors promote PTSD in genetically susceptible...