Synergistic effect of endocellular calcium ion release and nanotopograpy of one-dimensional hydroxyapatite nanomaterials for accelerating neural stem cell differentiation

Neural stem cells (NSCs) based nerve repair is the most promising approach for neurodegenerative disease therapy. However, the long-time requirement for NSCs differentiation into mature neurons challenges the clinical applications of NSCs because of the missing of the best opportunity for nerve repair. In this work, we synthesized four kinds of one-dimensional (1D) hydroxyapatite (HAp) nanomaterials with different morphologies of short nanorod,...