The cognitive and behavioral effects of D-amphetamine and nicotine sensitization in adult zebrafish

Background Zebrafish are growing in use as a model for understanding drug dependence and addiction. Sensitization paradigms have been a useful tool in identifying mechanisms involved in drug-induced behavioral and neurological changes, but in zebrafish have tended to focus on locomotor, rather than cognitive, endpoints. Methods Here, we used a novel method, the FMP Y-maze, which measures continuous performance through a series of repeated binary...