The therapeutic potential of GLP‐1 receptor biased agonism
Abstract
Glucagon-like peptide-1 (GLP-1) receptor agonists are effective treatments for type 2 diabetes as they stimulate insulin release and promote weight loss through appetite suppression. Their main side effect is nausea. All approved GLP-1 agonists are full agonists across multiple signalling pathways. However, selective engagement with specific intracellular effectors, or biased agonism, has been touted as a means to improve GLP-1 agonists...
Paper Details
Title
The therapeutic potential of GLP‐1 receptor biased agonism
Published Date
May 20, 2021
Volume
179
Issue
4
Pages
492 - 510
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