Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity

Volume: 296, Pages: 100693 - 100693
Published: Jan 1, 2021
Abstract
Speckle-type POZ protein (SPOP) is a ubiquitin ligase adaptor that binds substrate proteins and facilitates their proteasomal degradation. Most SPOP substrates present multiple SPOP-binding (SB) motifs and undergo liquid–liquid phase separation with SPOP. Pancreatic and duodenal homeobox 1 (Pdx1), an insulin transcription factor, is downregulated by interaction with SPOP. Unlike other substrates, only one SB motif has previously been reported...
Paper Details
Title
Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity
Published Date
Jan 1, 2021
Volume
296
Pages
100693 - 100693
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