Intestinal cell models for investigating the uptake, metabolism and absorption of dietary nutrients and bioactive compounds

The Caco-2 human intestinal cell line has been widely adopted to mimic the in vivo small intestinal epithelium for screening the characteristics and mechanisms of the uptake, metabolism and absorption of dietary compounds and drugs. Marked advances in stem cell biology and tissue engineering have led to the development of novel organoid and microfluidic models that better replicate key aspects of the physiology of the human gut and are expected...