Synthesis and biological studies of c(RGDyK) conjugates of cucurbitacins
Abstract
Cucurbitacins (CUCUs) are triterpenoids known to display potent cytotoxic effects; however, their clinical application is limited due to poor pharmacokinetics and systemic toxicity. This work focuses on the development of c(RGDyK)-CUCU conjugates for the selective delivery of CUCUs to integrin-overexpressing cancer cells. The activity of the conjugates against various cancer cells was studied. They exhibited a mild cytostatic effect to six...
Paper Details
Title
Synthesis and biological studies of c(RGDyK) conjugates of cucurbitacins
Published Date
May 1, 2021
Journal
Volume
13
Issue
10
Pages
877 - 895
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History