Challenges in the Diagnosis of Pituitary Neuroendocrine Tumors

Detailed analysis of cytodifferentiation and hormone production has classified null neuroendocrine tumors (PitNETs) in a formal system that reflects the lineage differentiation of nontumorous adenohypophysial cells as well as subtypes of tumors that have predictive value. In addition, tumors composed of cells that lack terminal differentiation are well characterized. To comply with the proposal to create an overarching classification of...