Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release

Encapsulation of small molecule drugs in long‐circulating lipid nanoparticles (LNPs) can reduce toxic side effects and enhance accumulation at tumor sites. A fundamental problem, however, is the slow release of encapsulated drugs from these liposomal systems at the disease site resulting in limited therapeutic benefit. Methods to trigger release at specific sites are highly warranted. Here, it is demonstrated that incorporation of ultraviolet...