Virus-Derived Peptides for Hepatic Enzyme Delivery
Abstract
Recently, a lipopeptide derived from the hepatitis B virus (HBV) large surface protein has been developed as an HBV entry inhibitor. This lipopeptide, called MyrcludexB (MyrB), selectively binds to the sodium taurocholate cotransporting polypeptide (NTCP) on the basolateral membrane of hepatocytes. Here, the feasibility of coupling therapeutic enzymes to MyrB was investigated for the development of enzyme delivery strategies. Hepatotropic...
Paper Details
Title
Virus-Derived Peptides for Hepatic Enzyme Delivery
Published Date
Apr 12, 2021
Journal
Volume
18
Issue
5
Pages
2004 - 2014
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Notes
History