ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer

Volume: 40, Issue: 19, Pages: 3394 - 3407
Published: Apr 19, 2021
Abstract
Poorly differentiated colorectal cancer (CRC) is characterized by aggressive invasion and stromal fibroblast activation, which results in rapid progression and poor therapeutic consequences. However, the regulatory mechanism involved remains unclear. Here, we showed that ZNF37A, a member of KRAB-ZFP family, was upregulated in poorly differentiated CRCs and associated with tumor metastasis. ZNF37A enhanced the metastatic potential of multiple CRC...
Paper Details
Title
ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer
Published Date
Apr 19, 2021
Journal
Volume
40
Issue
19
Pages
3394 - 3407
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