Age-related increase in matrix stiffness downregulates α-Klotho in chondrocytes and induces cartilage degeneration

Published: Mar 14, 2021
Abstract
Enhanced mechanistic insight into age-related knee osteoarthritis (KOA) is an essential step to promote successful translation of animal research to bedside interventions. To this end, the goal of these studies was to interrogate molecular mechanisms driving age-related KOA in a mouse model and correspond findings to human knee cartilage. Unbiased mass spectrometry proteomics of cartilage tissue revealed PI3K/Akt signaling was the predominant...
Paper Details
Title
Age-related increase in matrix stiffness downregulates α-Klotho in chondrocytes and induces cartilage degeneration
Published Date
Mar 14, 2021
Journal
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