Local production of lactate, ribose phosphate, and amino acids by human triple-negative breast cancer

Upregulated glucose metabolism is a common feature of tumors. Glucose can be broken down by either glycolysis or the oxidative pentose phosphate pathway (oxPPP). The relative usage within tumors of these catabolic pathways remains unclear. Similarly, the extent to which tumors make biomass precursors from glucose, versus take them up from the circulation, is incompletely defined.We explore human triple negative breast cancer (TNBC) metabolism by...