Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T Clinical Scanner

Published on Apr 28, 2019
Mina Kim3
Estimated H-index: 3
M Battiston4
Estimated H-index: 4
+ 7 AuthorsXavier Golay60
Estimated H-index: 60
#1Kevin J. Ray (University of Oxford)H-Index: 6
#2Manon A. Simard (Medical Research Council)H-Index: 4
Last. Nicola R. Sibson (Medical Research Council)H-Index: 46
view all 9 authors...
Abnormal pH is a common feature of malignant tumors and has been associated clinically with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) holds promise as a means to noninvasively measure tumor pH, yet multiple factors collectively make quantification of tumor pH from APT MRI data challenging. The purpose of this study was to improve our understanding of the biophysical sources of altered APT MRI signals in tumors. Combining in vivo APT MRI measurements with ex ...
28 CitationsSource
#1Moritz Zaiss (MPG: Max Planck Society)H-Index: 28
#2Kai Herz (MPG: Max Planck Society)H-Index: 8
Last. Klaus Scheffler (MPG: Max Planck Society)H-Index: 76
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Abstract Purpose Dynamic CEST studies such as dynamic glucose enhanced imaging, have gained a lot of attention recently. The expected CEST effects after injection are rather small in tissue especially at clinical field strengths (0.5–2%). Small movements during the dynamic CEST measurement together with a subtraction-based evaluation can lead to pseudo CEST effects of the same order of magnitude. These artifacts are studied herein. Methods A brain tumor patient 3D-CEST baseline scan without gluc...
24 CitationsSource
#1Asli Ercan Dogan (McLean Hospital)H-Index: 1
#2Cagri Yuksel (Harvard University)H-Index: 13
Last. Dost Öngür (Harvard University)H-Index: 60
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Converging evidence from molecular to neuroimaging studies suggests brain energy metabolism abnormalities in both schizophrenia and bipolar disorder. One emerging hypothesis is: decreased oxidative phosphorylation leading to accumulation of lactic acid from glycolysis and subsequent acidification of tissue. In this regard, integrating lactate and pH data from magnetic resonance spectroscopy (MRS) studies in both diseases may help us understand underlying neurobiological mechanisms. In order to a...
39 CitationsSource
#1Xiaolei Song (Johns Hopkins University)H-Index: 18
#2Jiadi Xu (Johns Hopkins University)H-Index: 34
Last. Michael T. McMahon (Johns Hopkins University)H-Index: 45
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Purpose The aim of this study was to develop a technique for rapid collection of chemical exchange saturation transfer images with the saturation varied to modulate signal loss transfer and enhance contrast. Methods Multi-echo Length and Offset VARied Saturation (MeLOVARS) divides the saturation pulse of length Tsat into N = 3–8 submodules, each consisting of a saturation pulse with length of Tsat/N (∼0.3–1 s), one or more low flip-angle gradient-echo readout(s) and a flip back pulse. This resul...
22 CitationsSource
#1Liu Qi Chen (UA: University of Arizona)H-Index: 9
#2Christine M. Howison (UA: University of Arizona)H-Index: 15
Last. Mark D. PagelH-Index: 12
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Purpose A practical, noninvasive method is needed to measure the extracellular pH (pHe) within in vivo tumors to longitudinally monitor tumor acidosis. We have optimized a biomedical imaging method, termed acidoCEST MRI, to provide noninvasive assessments of tumor pHe in preclinical models of mammary carcinoma. Methods A CEST-FISP MRI method was optimized to detect the chemical exchange saturation transfer (CEST) of two amide protons of a clinically approved CT contrast agent, iopromide. The rat...
134 CitationsSource
#1Olga Ciccarelli (UCL: University College London)H-Index: 73
#2Frederik Barkhof (VUmc: VU University Medical Center)H-Index: 177
Last. David Harry Miller (UCL: University College London)H-Index: 232
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Summary The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that underpin relapse-associated and progressive disability. Disease mechanisms can be investigated in preclinical models and patients with multiple sclerosis by molecular and metabolic imaging techniques. Many insights have been gained from such imaging studies: persisting inflammation in the absence of a damaged blood–brain barrier, activated microglia within and beyond lesions, increased mitochondrial ...
154 CitationsSource
#1Dario Livio Longo (UNITO: University of Turin)H-Index: 28
#2Walter Dastrù (UNITO: University of Turin)H-Index: 19
Last. Silvio Aime (UNITO: University of Turin)H-Index: 91
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Iopamidol (Isovue®—Bracco Diagnostic Inc.) is a clinically approved X-Ray contrast agent used in the last 30 years for a wide variety of diagnostic applications with a very good clinical acceptance. Iopamidol contains two types of amide functionalities that can be exploited for the generation of chemical exchange saturation transfer effect. The exchange rate of the two amide proton pools is markedly pH-dependent. Thus, a ratiometric method for pH assessment has been set-up based on the compariso...
147 CitationsSource
#1Virginia Kilia (University of Patras)H-Index: 2
#2Spyros S. Skandalis (University of Patras)H-Index: 25
Last. Nickoletta Papageorgakopoulou (University of Patras)H-Index: 9
view all 6 authors...
Recent advances in the structural biology of chondroitin sulfate chains have suggested important biological functions in the development of the brain. Several studies have demonstrated that the composition of chondroitin sulfate chains changes with aging and normal brain maturation. In this study, we determined the concentration of all glycosaminoglycan types, i.e. chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan sulfate, hyaluronan and chondroitin in cerebrum, cerebellum and brai...
3 CitationsSource
#1Manuel A. Friese (Medical Research Council)H-Index: 35
#2Matthew Craner (John Radcliffe Hospital)H-Index: 14
Last. Lars Fugger (Medical Research Council)H-Index: 71
view all 8 authors...
Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
320 CitationsSource
#1Michael T. McMahon (ICSCI: Kennedy Krieger Institute)H-Index: 45
#2Assaf A. Gilad (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 36
Last. Peter C.M. van Zijl (ICSCI: Kennedy Krieger Institute)H-Index: 109
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Chemical exchange saturation transfer (CEST) has recently been proposed as a new imaging contrast mechanism (1) in which the radiofrequency-induced saturation of labile protons in the agent is transferred to water protons. The resulting MRI signal intensity depends on a multitude of parameters, including agent concentration, number of exchangeable protons, proton exchange rate, T1, T2, saturation time, and saturation efficiency (1–8). Of these, the chemical exchange rate is often the parameter o...
257 CitationsSource
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