Persistence of circulating T-follicular helper cells after rituximab is associated with relapse of IgG4-related disease

Dear Editor, T-follicular helper (Tfh) cells have been implicated in the pathogenesis of a variety of autoimmune disorders because of their central role in adaptive immune responses [1]. In particular, Tfh cells orchestrate germinal centre reactions by recruiting CXCR5-expressing B-lymphocytes via CXCL13 secretion, and control antigen-dependent maturation, isotype class-switching, and somatic hypermutation of naïve B-cells [1]. IgG4-related...