Screening of potent phytochemical inhibitors against SARS-CoV-2 protease and its two Asian mutants

COVID-19, declared a pandemic in March 2020 by the World Health Organization is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The virus has already killed more than 2.3 million people worldwide. The principal intent of this work was to investigate lead compounds by screening natural product library (NPASS) for possible treatment of COVID-19. Pharmacophore features were used to screen a large database to get a small...